: AstraZeneca to supply U.S. with extra 500,000 doses of COVID-19 antibody-based cocktail



 said on Tuesday that it will supply the U.S. government with an additional 500,000 doses of its experimental, long-acting antibody-based COVID-19 combination treatment that aims to protect those who are not able to be vaccinated.

The $205 million agreement to supply the treatment — called AZD7442 — builds on a deal the Anglo-Swedish drug manufacturer struck last year with the Department of Health and Human Services and the Department of Defense (DoD).

Read: AstraZeneca advances COVID-19 antibody combo

Under that deal, announced in October, the U.S. invested $486 million for the development and supply of 100,000 doses of AZD7442, with an option to acquire up to an additional one million doses in 2021.

AstraZeneca has a separate agreement to supply the DoD with 100,000 doses, bringing potential U.S. supplies of the treatment to 700,000 doses in 2021, and the total value of current agreements with the U.S. government to $726 million.

Read: Germany and France become latest countries to halt use of AstraZeneca COVID-19 vaccine over blood clot concerns

Shares in FTSE 100-listed AstraZeneca
which are down 1.83% so far this year, rose 3.06% in early morning trading in London.

AstraZeneca Chief Executive Pascal Soriot said the long-acting antibody combination has the potential to offer “almost immediate protection” to those who are not able to be vaccinated, to both prevent infection or treat the disease in patients already infected with the virus.

“The U.S. government’s support is critical in helping accelerate the development of AZD7442, which we believe will be an important tool in the fight against COVID-19,” Soriot said.

His comments come a day after several European countries suspended the rollout of AstraZeneca’s vaccine over reports of possible side effects, including several incidents of blood clots in individuals who had received the vaccine, which was developed with researchers at the University of Oxford.

AstraZeneca, the World Health Organization, and the European Medicines Agency have all said the vaccine is safe, and that there is no link between the shot and reported blood clots.

AZD7442 — a combination of two monoclonal antibodies (mAbs) — is currently being evaluated for the prevention and treatment of COVID-19 in late-stage trials in more than 9,000 participants around the world.

Other drug manufacturers are also developing antibody treatments aimed at reducing the severity of coronavirus disease among patients diagnosed with the infection.

Read: Vir Biotechnology shares surge after COVID-19 antibody drug shown to reduce risk of death

Last week, Vir Biotechnology

and GlaxoSmithKline

said they planned to seek emergency-use authorization for their experimental COVID-19 antibody therapy, after interim data from a study showed 85% reduction in hospitalization and deaths among patients.

If authorized, the treatment would add to the antibody drugs available, after those developed by Eli Lilly

and Regeneron

were given emergency-use authorization in November.

AstraZeneca said on Tuesday that it doesn’t expect its agreement to supply up to 500,000 additional doses of AZD7442 to the U.S. to affect its financial guidance for 2021.

Morgan Stanley

said in a research note in December that AstraZeneca’s long-acting COVID-19 antibody cocktail could boost 2021 earnings by 30%, with positive data potentially being published early this year.

The new agreement is contingent on the treatment receiving emergency-use authorization from the U.S. Food and Drug Administration, AstraZeneca said.

Read: AstraZeneca sold its stake in Moderna for more than $1 billion, as it looks to develop its own pipeline of drugs

In a separate announcement, AstraZeneca said it completed the divestment of its 26.7% take in Viela Bio
as part of the proposed acquisition of Viela by Horizon Therapeutics

 for $775 million.


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